Custom Enzymes and Inhibitors
eMolecules 899898-94-3 | ChemScene | 1-(11-Dimethylethyl) 2-methyl (2S4S)-4-fluoro-5-oxo-12-pyrrolidinedicarboxylate | 25mg | 801476562 | CS-0461321 | MFCD18384496 | 144.125 | C6H6F2N2
ChemScene | 1-(11-Dimethylethyl) 2-methyl (2S4S)-4-fluoro-5-oxo-12-pyrrolidinedicarboxylate | 25mg | 801476562 | CS-0461321 | 899898-94-3 | MFCD18384496 | 144.125 | C6H6F2N2
Medchemexpress LLC HY-107613 10mg Medchemexpress, R 59-022 CAS:93076-89-2 Purity:>98%
Medchemexpress, HY-107613 10mg R 59-022 CAS:93076-89-2 R 59-022 (DKGI-I) is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[3][4]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Saracatinib (AZD0530) 200mg 379231-04-6
Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM in cell-free assays, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). Saracatinib induces autophagy. Phase 2/3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC CCI-006 5mg | 292053-42-0 | 5 MG
CCI-006 is a research-grade small molecule that inhibits mitochondrial respiration and acts as a chemosensitizer in MLL-rearranged leukemia cells. Supplied as a high-purity solid for in vitro research use only.
- High purity suitable for in vitro studies.
- Molecular weight 332.33 g/mol.
- Molecular formula C15H12N2O5S.
- Light yellow to yellow solid physical form.
- Intended for laboratory research use, not for human or diagnostic use.
eMolecules 118632-64-7 | N'-(Aminoiminomethyl)-N,N-dimethylurea | Toronto Research Chemicals | MFCD11035729 | 130.151 | C4H10N4OCN(C)C(=O)NC(N)=N | 250mg | 601589322
N'-(Aminoiminomethyl)-N,N-dimethylurea | Toronto Research Chemicals | 118632-64-7 | MFCD11035729 | 130.151 | C4H10N4OCN(C)C(=O)NC(N)=N | 250mg | 601589322
Medchemexpress LLC Amxi-5001 hydrochloride | 98.1% | C25H21ClFN5O3 | 50 MG
AMXI-5001 hydrochloride is a potent, orally active, and dual PARP1/2 and microtubule polymerization inhibitor. It exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells, with much lower IC50s than existing clinical PARP1/2 inhibitors. This compound induces complete regression of established tumors, including exceedingly large tumors. It is intended for research use only.
- Potent, orally active, and dual PARP1/2 and microtubule polymerization inhibitor
- Exhibits selective antitumor cytotoxicity across various human cancer cells
- Induces complete regression of established tumors, including large ones
Athens Research And Technology Inc Antithrombin III (ATIII, SERPINC1), Native Human Plasma, ≥95% (SDS-PAGE), 100 µg
Antithrombin III (ATIII, SERPINC1) is a native protein purified from human plasma with ≥95% (SDS-PAGE), supplied lyophilized in a 100 µg pack. Molecular weight: 58 kDa. Antithrombin III, Human Plasma: 100 UG; Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl; MW 58,000; EC=0.7; Purity: > =95% by SDS-PAGE;
Medchemexpress LLC Mc-val-cit-pab-indibulin | 2055896-95-0 | 95.8% | 945.48 | C50H55ClN9O8 | 5 MG
MC-Val-Cit-PAB-Indibulin is an antibody-drug conjugate (ADC) agent-linker conjugate that couples the MC-Val-Cit-PAB cleavable linker to indibulin for use in ADC research. It is supplied as a solid for research use only and is intended as a building block or payload-linker component for in vitro and in vivo antitumor studies.
- Agent-linker conjugate using indibulin as the cytotoxic payload.
- Molecular formula: C50H55ClN9O8; molecular weight: 945.48.
- High purity around 95.8% as provided by the supplier.
- Physical form: solid, light yellow to brown.
- Soluble in DMSO (125 mg/mL); example in vivo vehicle: 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline.
- Storage: keep sealed away from moisture; -20°C recommended; in solvent, store at -80°C for long-term.
- Intended for research use only and not for clinical or therapeutic use.
Athens Research And Technology Inc Alpha 2 Antiplasmin (SERPINF2), Native Human Plasma, ≥95% (SDS-PAGE), 1 mg
Alpha 2 Antiplasmin (SERPINF2) is a native protein purified from human plasma with ≥95% (SDS-PAGE), supplied lyophilized in a 1 mg pack. Molecular weight: 70 kDa. Alpha 2 Antiplasmin, Human Plasma: 1 MG; Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl; MW 70,000; EC= 0.7; Activity: > = 5.0 IU/mg; Purity: > =95% by SDS-PAGE; Inhibitor, Coagulation Factor.
Reprocell STEMOLECULE WNT INHB IWP-2 2MG
Stemolecule™ Wnt Inhibitor IWP-2. Stemolecule Wnt Inhibitor IWP-2 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.
Chemie Tek LCL-161, 10MG, 1005342-46-0
LCL-161 is an orally bioavailable and cell permeable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins.
Selleck Chemical LLC BI 2536 5mg 755038-02-9
BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Roflumilast 5mg 162401-32-3 APTA 2217, B9302-107, BY 217, BYK 20869
Roflumilast (APTA 2217, B9302-107, BY 217, BYK 20869) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM in a cell-free assay. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Amxi-5001 | 2170491-77-5 | MFCD34676674 | 98.3% | 457.46 | C25H20FN5O3 | 5 MG
AMXI-5001 is a small-molecule research compound described as a potent, orally active dual PARP1/2 and microtubule polymerization inhibitor with selective antitumor cytotoxicity in multiple human cancer cell lines; it has demonstrated tumor regression in preclinical studies.
- Potent dual PARP1/2 and microtubule polymerization inhibition.
- Selective antitumor cytotoxicity across various human cancer cell lines.
- High purity suitable for research applications.
- Soluble in DMSO at 50 mg/mL with warming and sonication recommended.
- Stable as a powder when stored at -20°C for long-term storage.
Enzo Life Sciences GYY 4137 (50mg). CAS: 106740-09-4
Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Shows vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells. Alternative name: 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt, Lawesson. Purity: ≥95%. Solubility: Soluble in water (30mg/ml) or DMSO (15mg/ml). Long Term Storage: -20°C.